How Long Does Vitamin K2 Stay in the Body?

How long does vitamin K2 stay in the body?

Vitamin K2 plays a pivotal role in our health. Including joint and brain health. The MK-7 form of vitamin K2 lingers in our system for 3-4 days, while MK-4 stays roughly 6 hours, with less active time. To harness its full potential, consider consuming K2-rich foods like cheese, eggs, and meat. These foods not only provide K2 but also other essential nutrients that synergize with it.


Vitamin K2, often overshadowed by its counterpart Vitamin K1, plays a pivotal role in our health, particularly in bone and heart health. While both vitamins are essential, K2 has unique properties that make it stand out. But how long does it stay in our system? As we delve deeper into the world of Vitamin K2, we’ll uncover the nuances of its different forms and their durations in the body, ensuring you’re well-informed about this vital nutrient.

Different Forms of Vitamin K2

Vitamin K2 isn’t just a singular entity; it comes in various forms, each with its own characteristics. The two most prominent forms we’ll focus on are MK-4 and MK-7. While they both serve the primary function of Vitamin K2, their duration in the body varies significantly. MK-4, for instance, has a relatively short stay, lasting up to 24 hours. On the other hand, MK-7 boasts a more extended presence, remaining in the body for up to three or four days. This difference in longevity is crucial, especially when considering dietary supplementation, as it can influence the effectiveness of the vitamin in our system.

The Longevity of MK-7

MK-7, often hailed as the superior form for dietary supplementation, has a unique advantage: its extended stay in the body. But why does it last longer? The answer lies in its bioavailability and half-life. When we consume MK-7, our body absorbs it efficiently, allowing it to reach its peak serum concentration about 4 hours after intake. This efficient absorption, combined with its longer half-life, means that MK-7 can stay active in our system for up to three or four days. Such longevity ensures that our body reaps the maximum benefits of this vitamin over an extended period.

The Shorter Stay of MK-4

In contrast to MK-7, MK-4 has a fleeting presence in our system. While it’s almost completely absorbed, peaking in serum concentration at around 2 hours post-intake, it doesn’t linger for long. MK-4 quickly vanishes from our circulation, making its active duration notably shorter. Specifically, Menaquinone, MK4, a version of K2, remains active for just about six hours. After this active phase, even though it might still be present in the body, it doesn’t necessarily function actively. This transient nature of MK-4 underscores the importance of understanding each form’s characteristics when considering Vitamin K2 supplementation.

Understanding Active vs. Inactive Duration

When discussing the presence of Vitamin K2 in our system, it’s crucial to differentiate between its active and inactive durations. Just because a vitamin is present doesn’t mean it’s actively benefiting our body. For instance, while Menaquinone, MK4, might stay in our body for more than six hours, it’s only actively functioning for about half that time. The remaining hours see the vitamin in a more dormant state, not actively contributing to our health. This distinction is vital, as it helps us gauge the true effectiveness of our Vitamin K2 intake and adjust our supplementation accordingly.

Why MK-7 is the Optimal Source

Given the research and the distinct characteristics of each form, MK-7 emerges as the optimal source of Vitamin K2 for most people. Studies, such as those by Schurgers et al., 2007 and Sato et al., 2012, highlight MK-7’s ability to accumulate in the bloodstream, staying in the body for approximately 72 hours. This extended presence, coupled with its superior bioavailability, makes MK-7 a preferred choice for those seeking the prolonged benefits of Vitamin K2. While both MK-4 and MK-7 have their merits, the longer, active presence of MK-7 in the bloodstream offers a more sustained advantage, especially when it comes to combating deficiencies and ensuring optimal health.

Factors Influencing Vitamin K2 Absorption

While the forms of Vitamin K2 inherently have different durations in the body, other factors can influence their absorption and efficacy. Dietary habits, the presence of healthy fats in meals, and individual metabolic rates can all play a role. For instance, consuming Vitamin K2 with a fat source can enhance its absorption, given its fat-soluble nature. Additionally, individual health conditions or medications might affect how one metabolizes these vitamins. Being aware of these factors can help individuals tailor their Vitamin K2 intake for maximum benefit.

Combining Vitamin K2 with Other Nutrients

Vitamin K2 doesn’t work in isolation. It often interacts synergistically with other vitamins and minerals, like Vitamin D and calcium, to promote optimal health. For instance, while Vitamin D aids calcium absorption, Vitamin K2 ensures that calcium is directed to the bones and teeth rather than depositing in arteries or joints. This collaborative action underscores the importance of a balanced nutrient intake and the potential benefits of combining Vitamin K2 with other supplements.


Vitamin K2, in its various forms, offers a plethora of health benefits, especially concerning bone and heart health. While both MK-4 and MK-7 have their unique advantages, MK-7’s longer duration in the body makes it a preferred choice for sustained benefits. However, understanding the active duration of each form, combined with individual factors and complementary nutrients, can help you make informed decisions about your Vitamin K2 intake.

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